A small glass of white wine a day could increase the
risk of skin cancer by 13 per cent, a study suggests. Drinking alcohol is
associated with higher rates of invasive melanoma and white wine carries the
greatest risk, according to the research. Those who drank a glass and a half of
wine a day increased the risk of developing melanomas on the torso - a rare
site of skin cancer - by up to 73 per cent compared with non-drinkers.
Each year, around 2,500 people die from malignant
melanoma in the UK. While the link between sun exposure and skin cancer is well
known, the fresh findings suggest white wine could lead to cancerous lesions in
areas of the body which are less exposed to the sun.
Study author Professor Eunyoung Cho, from Brown
University in the US, said: 'It was surprising that white wine was the only
drink independently associated with increased risk of melanoma. 'The reason for
the association is unknown. However, research has shown that some wine has
somewhat higher levels of pre-existing acetaldehyde than beer or spirits. 'While
red and white wine may have similar amounts of pre-existing acetaldehyde, the
antioxidants in red wine may offset the risks.'The clinical and biological
significance of these findings remains to be determined, but for motivated
individuals with other strong risk factors for melanoma, counselling regarding
alcohol use may be an appropriate risk-reduction strategy to reduce risks of
melanoma as well as other cancers.' Around 3.6 percent of cancer cases across
the world have been attributed to alcohol, including cancers of the liver,
pancreas, colon, rectum and breast.
This is because ethanol in alcohol can metabolise
into acetaldehyde, a chemical compound that can damage DNA and prevent DNA
repair. The researchers analysed the alcohol consumption of 210,250
participants in the three large cohort studies who were followed for 18 years. They
defined a standard drink as 12.8 g of alcohol. A unit of alcohol in the UK
contains around 8g of alcohol and a medium glass of white (175mls) wine
contains around two units. Each glass of white wine a day was associated with a
13 percent increased risk of the disease.
Meanwhile other forms of booze, including red wine,
beer and liquor, did not significantly affect melanoma risk because they don't
contain the same amounts of acetaldehyde. The researchers found the link
between alcohol and melanoma was strongest for parts of the body that typically
see less of the sun.
Compared to non-drinkers, those who consumed 20
grams of alcohol per day were 73 percent more likely to be diagnosed with
melanomas of the trunk, but just 2 percent more likely to be diagnosed with
melanomas of the head, neck or extremities.
The study, published in Cancer Epidemiology,
Biomarkers & Prevention, could pave the way for new risk-reduction
strategies among those with a family history of the disease. However, modest
alcohol intake has been connected with reduced risk of other medical conditions,
such as heart disease.
Professor Cho added, 'For drinkers, risks and
benefits of alcohol consumption have to be considered individually, including
the risk related to skin cancer.'
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